The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2007
Filed:
Aug. 01, 2000
Robert Henry Hesse, Winchester, MA (US);
Sundara Katugam Srinivasasetty Setty, Cambridge, MA (US);
Malathi Ramgopal, Andover, MA (US);
Robert Henry Hesse, Winchester, MA (US);
Sundara Katugam Srinivasasetty Setty, Cambridge, MA (US);
Malathi Ramgopal, Andover, MA (US);
Research Institute for Medicine and Chemistry, Inc., Cambridge, MA (US);
Abstract
Novel sterol derivatives of formula (I), in which: Rrepresents a hydroxyl group or protected hydroxyl group, Rrepresents a hydrogen atom and a double bond is present at c, or Rand Rtogether represent an oxo group and a double bond is present at b or double bonds are present at a and b; Rrepresents a methyl group having α- or β-configuration; Rand R, which may be the same or different, are selected from hydrogen atoms and aliphatic, cycloaliphatic, araliphatic and aryl groups, or together with the nitrogen atom to which they are attached form a heterocyclic group; and X represents a polymethylene group containing 2–5 carbon atoms, an oxa group-containing analogue thereof in which a methylene group other than that attached to the —CO.NRRmoiety is replaced by an oxygen atom, or an unsaturated analogue thereof containing up to two double bonds. Active compounds of the invention exhibit potent effects on the modulation of cell growth and differentiation and possess an advantageous therapeutic ratio by virtue of their low levels of calcaemic activity.