The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2007
Filed:
Jul. 09, 2004
Ranjit Ray, Saint Louis, MO (US);
Ratna Ray, Saint Louis, MO (US);
Arnab Basu, Kolkata, IN;
Yie-hwa Chang, Saint Louis, MO (US);
Ranjit Ray, Saint Louis, MO (US);
Ratna Ray, Saint Louis, MO (US);
Arnab Basu, Kolkata, IN;
Yie-Hwa Chang, Saint Louis, MO (US);
Saint Louis University, St. Louis, MO (US);
Abstract
The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocytes as containing a death factor that induces apoptosis of activated liver stellate cells. This pro-apoptotic activity is shown to be associated with an 80 kDa protein, which is associated with a fetuin peptide sequence and an albumin peptide sequence.