The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 19, 2007

Filed:

Aug. 18, 2004
Applicants:

Hector F. Deluca, Deerfield, WI (US);

Rafal R. Sicinski, Madison, WI (US);

Sumithra Gowlugari, Fremont, CA (US);

Inventors:

Hector F. DeLuca, Deerfield, WI (US);

Rafal R. Sicinski, Madison, WI (US);

Sumithra Gowlugari, Fremont, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/59 (2006.01); C07C 401/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

2-Methylene-19-nor-24(S) and 24(R) derivatives of 1α,25-dihydroxyvitamin Dare disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment of diseases such as renal osteodystrophy, autoimmune diseases, and osteoporosis. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anticancer agents and for use treating skin diseases such as psoriasis


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