The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 29, 2007
Filed:
Oct. 21, 2003
Michael S. Brown, Dallas, TX (US);
Jin YE, Dallas, TX (US);
Chunfu Wang, Dallas, TX (US);
Rhea Sumpter, Jr., Dallas, TX (US);
Joseph L. Goldstein, Dallas, TX (US);
Michael Gale, Jr., Dallas, TX (US);
Michael S. Brown, Dallas, TX (US);
Jin Ye, Dallas, TX (US);
Chunfu Wang, Dallas, TX (US);
Rhea Sumpter, Jr., Dallas, TX (US);
Joseph L. Goldstein, Dallas, TX (US);
Michael Gale, Jr., Dallas, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
Permissiveness of human cells to replication of susceptible pathogenic human viruses is reduced by treating the cells with a selective inhibitor of prenylation of a host cell protein. Target viruses, especially Flaviviridae, are predetermined to lack a CXXX box and prenylated viral protein, and to be replication-dependent on host protein prenylation. The general method comprises (a) contacting human cells subject to infection by the virus with an effective amount of a selective inhibitor of a prenylation enzyme of the cells; and (b) confirming a resultant reduction in permissiveness of the cells to replication of the virus. Targeted enzymes include prenyl biosynthetic enzyme like HMG CoA reductase farnesyl and/or geranylgeranyl transferase enzymes.