The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 08, 2007

Filed:

May. 05, 2003
Applicants:

Jon A. Wolff, Madison, WI (US);

Vladimir G. Budker, Middleton, WI (US);

James E. Hagstrom, Middleton, WI (US);

Julia Hegge, Monona, WI (US);

Vladimir Subbotin, Madison, WI (US);

Inventors:

Jon A. Wolff, Madison, WI (US);

Vladimir G. Budker, Middleton, WI (US);

James E. Hagstrom, Middleton, WI (US);

Julia Hegge, Monona, WI (US);

Vladimir Subbotin, Madison, WI (US);

Assignee:

Mirus Bio Corporation, Madison, WI (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.


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