The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Jul. 19, 2002
Applicants:
Thomas F. Zioncheck, Montara, CA (US);
Geralyn G. Deguzman, Daly City, CA (US);
Rodney Gene Keck, Castro Valley, CA (US);
Inventors:
Thomas F. Zioncheck, Montara, CA (US);
Geralyn G. DeGuzman, Daly City, CA (US);
Rodney Gene Keck, Castro Valley, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/475 (2006.01); A61K 38/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
Described herein are pharmaceutical compositions including vascular endothelial cell growth factor (VEGF) variants having modifications in the C-terminal heparin binding domain. The variants exhibit reduced clearance rates for systemic administration generally at lower doses compared with native VEGF thus providing variants having longer availability for therapeutic effect.