The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2007
Filed:
Jan. 21, 2004
Anthony J. F. D′apice, Balwyn, AU;
Martin J. Pearse, Mordialloc, AU;
Allan J. Robins, Waterloo Corner, AU;
Robert J. Crawford, West Lake Shores, AU;
Peter D. Rathjen, Blackwood, AU;
Anthony J. F. d′Apice, Balwyn, AU;
Martin J. Pearse, Mordialloc, AU;
Allan J. Robins, Waterloo Corner, AU;
Robert J. Crawford, West Lake Shores, AU;
Peter D. Rathjen, Blackwood, AU;
BresaGen Limited, Thebarton SA, AU;
St. Vincent's Hospital, Victoria, AU;
Abstract
Human pre-formed xenoantibodies play an important role in the hyperacute rejection response in human xenotransplantation. Disclosed are materials and methods for removing or neutralizing such antibodies. Also disclosed are materials and methods for reducing or eliminating the epitopes in the donor organs that are recognized by such antibodies. Such epitopes are formed as the result of activity by the enzyme α-1,3 galactosyltransferase. The porcine gene encoding α-1,3 galactosyltransferase is disclosed, as are materials and methods for inactivating ('knocking out') the α-1,3 galactosyltransferase gene in mammalian cells and embryos. Included are nucleic acid constructs useful for inactivating the α-1,3 galactosyltransferase gene in a target cell. Also disclosed is a novel leukemia inhibitory factor (T-LIF) that is useful for maintenance of embryonic stem cells and primordial germ cells in culture.