The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 27, 2007

Filed:

Jan. 22, 2003
Applicants:

Olaf Heidenreich, Tübgingen, DE;

Hans-peter Vornlocher, Bayreuth, DE;

Roland Kreutzer, Weidenberg, DE;

Stefan Limmer, Neudrossenfeld, DE;

Inventors:

Olaf Heidenreich, Tübgingen, DE;

Hans-Peter Vornlocher, Bayreuth, DE;

Roland Kreutzer, Weidenberg, DE;

Stefan Limmer, Neudrossenfeld, DE;

Assignee:

Alnylam Europe AG, Kulmbach, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to the specific inhibition of expression of a fusion gene in mammals using a short double stranded RNA. The dsRNA is approximately 19–24 nucleotides in length, and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs of the present invention are useful for treating diseases caused by chromosomal aberrations, particularly malignant diseases such as lymphoma and leukemia.


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