The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 20, 2007
Filed:
Sep. 26, 2002
Stefanie A. Kane, Schwenksville, PA (US);
Christopher A. Salvatore, Philadelphia, PA (US);
John J. Mallee, Collegeville, PA (US);
Kenneth S. Koblan, Carversville, PA (US);
Kevin R. Oliver, Huntingdon, GB;
Stefanie A. Kane, Schwenksville, PA (US);
Christopher A. Salvatore, Philadelphia, PA (US);
John J. Mallee, Collegeville, PA (US);
Kenneth S. Koblan, Carversville, PA (US);
Kevin R. Oliver, Huntingdon, GB;
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Disclosed herein are isolated nucleic acid molecules encoding a humanized version of a calcitonin gene-related peptide (CGRP) receptor, which comprises the G-protein coupled receptor calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein 1 (RAMP1). The humanized CGRP receptors of the present invention attain pharmacological profiles similar to the wild type human receptor via modifications to the respective mammalian RAMP1 nucleotide sequence, specifically at amino acid 74. Also described are related recombinant vectors, recombinant hosts and associated methods for generating such humanized CGRP receptors. Also presented are non-human transgenic animals which express humanized RAMP1. Such animals have been engineered to provide for a CGRP pharmacological profile similar to human CGRP.