The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 06, 2007
Filed:
Sep. 19, 2003
Anthony M. Manning, Lake St. Louis, MO (US);
Frank Mercurio, San Diego, CA (US);
Sharo Amit, Beer-Sheba, IL;
Yinon Ben-neriah, Zion, IL;
Matti Davis, Jerusalem, IL;
Ada Hatzubai, Kibutz Palmah-Zova, IL;
Avraham Yaron, Jerusalem, IL;
Irit Alkalay, Jerusalem, IL;
Aaron Ciechanover, Haifa, IL;
Anthony M. Manning, Lake St. Louis, MO (US);
Frank Mercurio, San Diego, CA (US);
Sharo Amit, Beer-Sheba, IL;
Yinon Ben-Neriah, Zion, IL;
Matti Davis, Jerusalem, IL;
Ada Hatzubai, Kibutz Palmah-Zova, IL;
Avraham Yaron, Jerusalem, IL;
Irit Alkalay, Jerusalem, IL;
Aaron Ciechanover, Haifa, IL;
Signal Pharmaceuticals LLC, San Diego, CA (US);
Abstract
Compositions and methods for modulating the activation of nuclear factor κB (NF-κB) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated IκBα and/or IκBβ. Such compositions may be used for treating diseases associated with NF-κB activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.