The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2007
Filed:
Apr. 11, 2002
David G. Gorenstein, Houston, TX (US);
David J. King, Galveston, TX (US);
Daniel A. Ventura, Galveston, TX (US);
Allan R. Brasier, Galveston, TX (US);
David G. Gorenstein, Houston, TX (US);
David J. King, Galveston, TX (US);
Daniel A. Ventura, Galveston, TX (US);
Allan R. Brasier, Galveston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio-substituted aptamers are provided that bind tightly to the nuclear factor for human IL6 (NF-IL6).