The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2007
Filed:
Feb. 26, 2004
John J. Baldwin, Gwynedd Valley, PA (US);
Edward Mcdonald, Surrey, GB;
Kevin Joseph Moriarty, Norristown, PA (US);
Christopher Ronald Sarko, New Milford, CT (US);
Nobuo Machinaga, Tokyo, JP;
Atsushi Nakayama, Tokyo, JP;
Jun Chiba, Tokyo, JP;
Iimura Shin, Tokyo, JP;
Yoshiyuki Yoneda, Tokyo, JP;
John J. Baldwin, Gwynedd Valley, PA (US);
Edward McDonald, Surrey, GB;
Kevin Joseph Moriarty, Norristown, PA (US);
Christopher Ronald Sarko, New Milford, CT (US);
Nobuo Machinaga, Tokyo, JP;
Atsushi Nakayama, Tokyo, JP;
Jun Chiba, Tokyo, JP;
Iimura Shin, Tokyo, JP;
Yoshiyuki Yoneda, Tokyo, JP;
Daiichi Pharmaceutical Co., Ltd., Tokyo, JP;
Pharmacopeia Drug Discovery, Inc., Cranbury, NJ (US);
Abstract
Compounds that selectively inhibit the binding of ligands to α4β1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion.