The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2007
Filed:
Jul. 29, 2002
Evelyn Wang, Haddonfield, NJ (US);
Rocco Casagrande, Newton, MA (US);
Amar Kendale, Somerville, MA (US);
Enoch Kim, Boston, MA (US);
Emanuele Ostuni, Watertown, MA (US);
Olivier Schueller, Somerville, MA (US);
Evelyn Wang, Haddonfield, NJ (US);
Rocco Casagrande, Newton, MA (US);
Amar Kendale, Somerville, MA (US);
Enoch Kim, Boston, MA (US);
Emanuele Ostuni, Watertown, MA (US);
Olivier Schueller, Somerville, MA (US);
Surface Logix, Inc., Brighton, MA (US);
Abstract
The present invention provides methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the present invention provides for delivering cell(s) to a plurality of cell isolation regions of a cell isolation device, transferring the cell(s) to a plurality of wells of a cell expansion device and detecting the potential desired biological activity of the cell(s). Each of the cell isolation regions comprise a bioaffinity region capable of binding a single cell or a small group of cell(s). This binding of cell(s) may be accomplished through the use of bioaffinity ligands immobilized in the bioaffinity regions of the cell isolation regions. Preferably, the wells of the cell expansion device encompass a cavity that provides sufficient volume for cell proliferation.