The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2007
Filed:
Nov. 02, 2004
Jian NI, Germantown, MD (US);
Steven M. Ruben, Brookeville, MD (US);
Laurie A. Brewer, St. Paul, MD (US);
Reiner L. Gentz, Belo Horizonte-Mg, BR;
Craig A. Rosen, Laytonsville, MD (US);
Jian Ni, Germantown, MD (US);
Steven M. Ruben, Brookeville, MD (US);
Laurie A. Brewer, St. Paul, MD (US);
Reiner L. Gentz, Belo Horizonte-Mg, BR;
Craig A. Rosen, Laytonsville, MD (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.