The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2006
Filed:
Dec. 17, 2002
Carl Arne Krister Borrebaeck, Hjarup, SE;
Ann-christin Malmborg-hager, Helsingborg, SE;
Christina Furebring, Lund, SE;
Ulf Hans Eskil Soderlind, Sòdra Sandby, SE;
Rebecka Ingrid Camilla Ottosson, Lund, SE;
Carl Arne Krister Borrebaeck, Hjarup, SE;
Ann-Christin Malmborg-Hager, Helsingborg, SE;
Christina Furebring, Lund, SE;
Ulf Hans Eskil Soderlind, Sòdra Sandby, SE;
Rebecka Ingrid Camilla Ottosson, Lund, SE;
Alligator Bioscience AB, Lund, SE;
Abstract
The present invention relates to a method for in vitro evolution of protein function. In particular, the method relates to the shuffling of nucleotide segments obtained from exonuclease digestion. The present inventors have shown that polynucleotide fragments derived from a parent polynucleotide sequence digested with an exonuclease can be combined to generate a polynucleotide sequence which encodes for a polypeptide having desired characteristics. This method may be usefully applied to the generation of new proteins (e.g., antibodies and enzymes) or parts thereof having modified characteristics as compared to the parent protein.