The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 26, 2006
Filed:
Jul. 25, 2003
Martin Friedlander, Del Mar, CA (US);
Atsushi Otani, San Diego, CA (US);
Karen Da Silva, Irvine, CA (US);
Martin Friedlander, Del Mar, CA (US);
Atsushi Otani, San Diego, CA (US);
Karen Da Silva, Irvine, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
Isolated, mammalian, bone marrow-derived, lineage negative hematopoietic stem cell populations (LinHSC) contain endothelial progenitor cells (EPC) capable of forming retinal blood vessels. At least about 50% of the cells in the isolated LinHSC population include cell surface markers for CD31 and c-kit. Up to about 8% of the cells can include the Sca-1 cell marker, and up to about 4% of the cells can include the Flk-1/KDR marker. The isolated LinHSC populations of the present invention are useful for treatment of ocular vascular diseases. The isolated LinHSC populations that have been transfected with therapeutically useful genes are also provided, which are useful for delivering genes to the eye for cell-based gene therapy.