The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 2006
Filed:
Dec. 22, 2003
Harren Jhoti, Cambridge, GB;
Miles Stuart Congreve, Cambridge, GB;
Marc O'reilly, Cambridge, GB;
Paul Graham Wyatt, Cambridge, GB;
Harren Jhoti, Cambridge, GB;
Miles Stuart Congreve, Cambridge, GB;
Marc O'Reilly, Cambridge, GB;
Paul Graham Wyatt, Cambridge, GB;
Astex Therapeutics Limited, Cambridge, GB;
Abstract
A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.