The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2006
Filed:
Apr. 22, 2004
Po-ying Chan-hui, Oakland, CA (US);
Yining Shi, San Jose, CA (US);
Sailaja Pidaparthi, Cupertino, CA (US);
Rajiv Dua, Manteca, CA (US);
Sharat Singh, San Jose, CA (US);
Po-Ying Chan-Hui, Oakland, CA (US);
Yining Shi, San Jose, CA (US);
Sailaja Pidaparthi, Cupertino, CA (US);
Rajiv Dua, Manteca, CA (US);
Sharat Singh, San Jose, CA (US);
Monogram Biosciences, Inc., South San Francisco, CA (US);
Abstract
Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes a molecular tag that is linked to a first binding compound through a cleavable linkage, and the cleaving probe includes a second binding agent and a cleavage-inducing moiety that can cleave the linkage when within a defined proximity thereto. Binding of the two probes to cell surface molecules that have formed an oligomeric complex results in release of the molecular tag from the binding compound, providing a measure of formation of the complex.