The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Oct. 04, 2001
Muthiah Manoharan, Carlsbad, CA (US);
Venkatraman Mohan, Plainsboro, NJ (US);
Phillip Dan Cook, Fallbrook, CA (US);
Andrew M. Kawasaki, San Diego, CA (US);
Muthiah Manoharan, Carlsbad, CA (US);
Venkatraman Mohan, Plainsboro, NJ (US);
Phillip Dan Cook, Fallbrook, CA (US);
Andrew M. Kawasaki, San Diego, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2' endo sugars or O4′ endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2′-O-modified nucleotides that have 3′ endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other.