The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Feb. 05, 2004
Jonathan A. Ellman, Oakland, CA (US);
Gary Lynch, Irvine, CA (US);
Irwin D. Kuntz, Greenbrae, CA (US);
Xiaoning BI, Irvine, CA (US);
Christina E. Lee, San Francisco, CA (US);
A. Geoffrey Skillman, San Francisco, CA (US);
Tasir Haque, Wilmington, DE (US);
Jonathan A. Ellman, Oakland, CA (US);
Gary Lynch, Irvine, CA (US);
Irwin D. Kuntz, Greenbrae, CA (US);
Xiaoning Bi, Irvine, CA (US);
Christina E. Lee, San Francisco, CA (US);
A. Geoffrey Skillman, San Francisco, CA (US);
Tasir Haque, Wilmington, DE (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention relates to () non-peptide aspartyl protease inhibitors; (ii) methods for modulating the processing of an amyloid precursor protein (APP); (iii) methods for modulating the processing of a tau protein (τ-protein); and (iv) methods for treating neurodegenerative diseases. For instance, in one embodiment, the present invention provides a method for modulating the processing of an amyloid precursor protein (APP), the method comprising contacting a composition containing the APP with an aspartyl protease inhibitor having the formula: wherein: RRand Rare members independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxyalkyl, substituted aryloxyalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycles, substituted heterocycles, heterocyclicalkyl and substituted heterocyclicalkyl; and Rand Rare independently selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxyalkyl and substituted aryloxyalkyl; or Rand Rand the carbons to which they are bound join to form an optionally substituted carbocyclic or heterocyclic fused ring system having a total of 9- or 10-ring atoms within the fused ring system.