The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Jul. 29, 2003
Christopher John Corcoran, Arlington, MA (US);
Carl R. Flannery, Acton, MA (US);
Weilan Zeng, Waltham, MA (US);
Lisa A. Racie, Acton, MA (US);
Thomas Mcdonagh, Acton, MA (US);
Bethany A. Freeman, Arlington, MA (US);
Katy E. Georgiadis, Belmont, MA (US);
Edward R. Lavallie, Harvard, MA (US);
Christopher John Corcoran, Arlington, MA (US);
Carl R. Flannery, Acton, MA (US);
Weilan Zeng, Waltham, MA (US);
Lisa A. Racie, Acton, MA (US);
Thomas McDonagh, Acton, MA (US);
Bethany A. Freeman, Arlington, MA (US);
Katy E. Georgiadis, Belmont, MA (US);
Edward R. LaVallie, Harvard, MA (US);
Wyeth, Madison, NJ (US);
Abstract
The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.