The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Apr. 15, 1998
Martin Roland Jensen, Holte, DK;
Søren Mouritsen, Birkerød, DK;
Henrik Elsner, Brønshøj, DK;
Iben Dalum, Hørsholm, DK;
Martin Roland Jensen, Holte, DK;
Søren Mouritsen, Birkerød, DK;
Henrik Elsner, Brønshøj, DK;
Iben Dalum, Hørsholm, DK;
Pharmexa A/S, Horsholm, DK;
Abstract
A modified human TNFα molecule is capable of raising neutralizing antibodies towards unmodified human TNFα following administration of the modified TNFα to a human host, wherein one or more peptide fragments of the human TNFα molecule has been substituted by one or more peptides containing immunodominant T cell epitopes or a truncated form of the molecule containing the immunodominant epitope and one or both flanking regions of the human TNFα-molecule containing at least one TNFα B cell epitope, wherein the substitution introduces a substantial change in the amino acid sequence of any one of the strands of the front β-sheet, in any one of the connecting loops, or in any one of the B', I, or D strands of the back β-sheet.