The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2006
Filed:
Aug. 08, 2003
JO E. Handelsman, Madison, WI (US);
Robert M. Goodman, Madison, WI (US);
Doreen E. Gillespie, Madison, WI (US);
Alan D. Bettermann, Madison, WI (US);
Jon C. Clardy, Ithaca, NY (US);
Sean F. Brady, Ithaca, NY (US);
Jo E. Handelsman, Madison, WI (US);
Robert M. Goodman, Madison, WI (US);
Doreen E. Gillespie, Madison, WI (US);
Alan D. Bettermann, Madison, WI (US);
Jon C. Clardy, Ithaca, NY (US);
Sean F. Brady, Ithaca, NY (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Disclosed are triaryl cationic compounds that exhibit broad spectrum antibiotic and antifungal activity, pharmaceutical compositions containing the compounds, and methods of treating bacterial and fungal infections using the compounds. The compounds were initially isolated by screening a 25,000-member bacterial artificial chromosome (BAC) library of environmental (eDNA) from soil. At least one clone produced a dark brown melanin-like compound that was found to have antibiotic activity. The compounds were isolated and synthesized de novo. From within the positive clone, a single open reading frame that shares extensive sequence similarity with members of the 4-hydroxyphenylpyruvate family of enzymes was found to be necessary and sufficient to confer the production of at least one of the subject compounds on