The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 03, 2006
Filed:
Jun. 11, 2001
Lesley B. Pickford, Menlo Park, CA (US);
Sanjeev Gangwar, Alameda, CA (US);
Thomas J. Lobl, Valencia, CA (US);
Matthew H. Nieder, Seattle, WA (US);
Geoffrey T. Yarranton, Burlingame, CA (US);
Lesley B. Pickford, Menlo Park, CA (US);
Sanjeev Gangwar, Alameda, CA (US);
Thomas J. Lobl, Valencia, CA (US);
Matthew H. Nieder, Seattle, WA (US);
Geoffrey T. Yarranton, Burlingame, CA (US);
Medarex, Inc., Princeton, NJ (US);
Abstract
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed.