The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2006
Filed:
Jan. 04, 2002
David Wallach, Rehovot, IL;
Mark P Boldin, Moscow, RU;
Eugene E Varfolomeev, Rehovot, IL;
Zeev Pancer, Mainz, DE;
Igor Mett, Rehovot, IL;
Tanya M Goncharov, Ashkelon, IL;
David Wallach, Rehovot, IL;
Mark P Boldin, Moscow, RU;
Eugene E Varfolomeev, Rehovot, IL;
Zeev Pancer, Mainz, DE;
Igor Mett, Rehovot, IL;
Tanya M Goncharov, Ashkelon, IL;
Yeda Research and Development Co. Ltd., Rehovot, IL;
Abstract
A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a 'death domain' motif is provided. The 'death domain' is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with ‘death domain’ motifs within p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the ‘death domain’.