The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2006
Filed:
Dec. 22, 1999
Qinjian Zhao, Ambler, PA (US);
Robert Sitrin, Lafeyette Hill, PA (US);
Dicky G. Abraham, North Wales, PA (US);
David P. Gervais, Harleysville, PA (US);
Juan Gimenez, Lansdale, PA (US);
Qinjian Zhao, Ambler, PA (US);
Robert Sitrin, Lafeyette Hill, PA (US);
Dicky G. Abraham, North Wales, PA (US);
David P. Gervais, Harleysville, PA (US);
Juan Gimenez, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention provides an improved rHBsAg that exhibits a higher antigenicity and immunogenicity than that previously known in the art. A method of making the improved rHBsAg is also provided. The improved HBsAg is used to provide vaccines with lower amounts of active ingredient, vaccines with higher immunogenicity and combination vaccines which produce and protective immunization against infection by hepatitis B virus and other infectious agents.