The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2006
Filed:
Oct. 24, 2002
Aeri Kim, Daejeon, KR;
Kwan Hyung Cho, Daejeon, KR;
Sun Hwa Lee, Daejeon, KR;
Suk Kyoon Yoon, Daejeon, KR;
Hee Dong Park, Daejeon, KR;
Kyung Ha Chung, Daejeon, KR;
Ho Jun Kim, Daejeon, KR;
Han Joo Maeng, Incheon, KR;
Tae Hun Kim, Daejeon, KR;
Bong Chan Kim, Daejeon, KR;
Sung Ji Kim, Daejeon, KR;
Aeri Kim, Daejeon, KR;
Kwan Hyung Cho, Daejeon, KR;
Sun Hwa Lee, Daejeon, KR;
Suk Kyoon Yoon, Daejeon, KR;
Hee Dong Park, Daejeon, KR;
Kyung Ha Chung, Daejeon, KR;
Ho Jun Kim, Daejeon, KR;
Han Joo Maeng, Incheon, KR;
Tae Hun Kim, Daejeon, KR;
Bong Chan Kim, Daejeon, KR;
Sung Ji Kim, Daejeon, KR;
LG Life Sciences Ltd., Seoul, KR;
Abstract
The present invention provides a method of predicting a food-drug interaction in vivo, in the case of an orally administered drug interactive with digestive enzymes in the gastrointestinal tract, by measuring the activity of the drug to the digestive enzymes in vitro, which is based on the fact that the ingestion of foods causes the absorption of drug in vivo to decrease due to the above interaction between a drug and digestive enzymes. The present invention further provides methods of minimizing the change of absorption in vivo caused by the ingestion of foods by reducing the action of digestive enzymes, for example, introduction of prodrugs, modification of the chemical structure of drug, design of drug formulation, etc.