The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Jul. 11, 2002
John Moore Maclennan, Bellingham, MA (US);
Robert Charles Ladner, Ijamsville, MD (US);
Thomas Cushman Ransohoff, Lexington, MA (US);
John Moore Maclennan, Bellingham, MA (US);
Robert Charles Ladner, Ijamsville, MD (US);
Thomas Cushman Ransohoff, Lexington, MA (US);
Dyax Corp., Cambridge, MA (US);
Abstract
A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.