The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
Mar. 23, 2001
Bernhard Dietzschold, Newtown Square, PA (US);
D. Craig Hooper, Medford, NJ (US);
Matthias Schnell, Harleysville, PA (US);
Charles E. Rupprecht, Lawrenceville, GA (US);
Bernhard Dietzschold, Newtown Square, PA (US);
D. Craig Hooper, Medford, NJ (US);
Matthias Schnell, Harleysville, PA (US);
Charles E. Rupprecht, Lawrenceville, GA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Abstract
Live, attenuated recombinant rabies virus vaccines are generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response. These vaccines do not affect the antigenic, and therefore the immunogenic, properties of the virus. The present invention further relates to recombinant rabies virus vaccines that express a pro-apoptotic protein, such as cytochrome c, to increase the capacity to induce apoptosis, thereby enhancing the protective immunity against rabies. This new generation of live rabies virus vaccines represents a safe and effective approach to the eradication of rabies in wildlife, and subsequently humans and livestock.