The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2006
Filed:
Jun. 30, 2003
Applicants:
Michael A. Wall, Portland, OR (US);
Mansukh C. Wani, Durham, NC (US);
Govindarajan Manikumar, Raleigh, NC (US);
Inventors:
Michael A. Wall, Portland, OR (US);
Mansukh C. Wani, Durham, NC (US);
Govindarajan Manikumar, Raleigh, NC (US);
Assignee:
Research Triangle Institute, Research Triangle Park, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/407 (2006.01); C07D 487/02 (2006.01); C07D 487/14 (2006.01);
U.S. Cl.
CPC ...
Abstract
Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.