The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2006
Filed:
Jul. 16, 2001
Applicants:
Thomas J. Graddis, Cupertino, CA (US);
Jeffrey T. Mcgrew, Seattle, WA (US);
Inventors:
Thomas J. Graddis, Cupertino, CA (US);
Jeffrey T. McGrew, Seattle, WA (US);
Assignee:
Immunex Corporation, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
Abstract
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.