The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2006
Filed:
Feb. 19, 2002
Dennis R. Burton, La Jolla, CA (US);
Roberto Burioni, Del Mar, CA (US);
R. Anthony Williamson, Del Mar, CA (US);
Pietro P. Sanna, San Diego, CA (US);
Dennis R. Burton, La Jolla, CA (US);
Roberto Burioni, Del Mar, CA (US);
R. Anthony Williamson, Del Mar, CA (US);
Pietro P. Sanna, San Diego, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precluding the capture antibody epitope from being presented to a population of antibodies to be screened. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies. An antibody specific for herpes simplex virus (HSV), was employed as a model for the assay.