The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Sep. 12, 2001
Etienne Daniel Francois Jacotot, Paris, FR;
Guido Kroemer, Paris, FR;
Bernard Pierre Roques, Paris, FR;
Lena Edelman, Boulogne, FR;
Johan Hoebeke, Schiltigheim, FR;
Catherine Brenner-jean, Survilliers, FR;
Anne-sophie Belzacq, Margny-les-Compiègne, FR;
Etienne Daniel Francois Jacotot, Paris, FR;
Guido Kroemer, Paris, FR;
Bernard Pierre Roques, Paris, FR;
Lena Edelman, Boulogne, FR;
Johan Hoebeke, Schiltigheim, FR;
Catherine Brenner-Jean, Survilliers, FR;
Anne-Sophie Belzacq, Margny-les-Compiègne, FR;
Institut Pasteur, Paris, FR;
Institut National de la Sante et de la Recherche Medicale, Paris, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Universite de Technologie de Compiegne, Compiegne, FR;
Abstract
The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.