The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2006
Filed:
Nov. 17, 2003
Jian NI, Germantown, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vishva M. Dixit, Los Altos Hills, CA (US);
Reiner L. Gentz, Belo Horizonte-Mg, BR;
Joseph J. Kenny, San Diego, CA (US);
Jian Ni, Germantown, MD (US);
Craig A. Rosen, Laytonsville, MD (US);
Vishva M. Dixit, Los Altos Hills, CA (US);
Reiner L. Gentz, Belo Horizonte-Mg, BR;
Joseph J. Kenny, San Diego, CA (US);
Human Genome Sciences, Inc., Rockville, MD (US);
The Regents of the University, Ann Arbor, MI (US);
Abstract
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.