The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2006
Filed:
May. 17, 2002
Peter Klein, Birkenheide, DE;
Marco Thyes, Ludwigshafen, DE;
Markus Grosse, Schwetzingen, DE;
Klaus Martin Weber, Ludwigshafen, DE;
Peter Klein, Birkenheide, DE;
Marco Thyes, Ludwigshafen, DE;
Markus Grosse, Schwetzingen, DE;
Klaus Martin Weber, Ludwigshafen, DE;
Abbott GmbH & Co. DG, Wiesbaden, DE;
Abstract
The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.