The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Dec. 06, 2001
Edward Rebar, El Cerrito, CA (US);
Andrew Jamieson, San Francisco, CA (US);
Qiang Liu, Foster City, CA (US);
Pei-qi Liu, Richmond, CA (US);
Elizabeth J. Wolffe, Orinda, CA (US);
Stephen P. Eisenberg, Boulder, CO (US);
Eric Jarvis, Boulder, CO (US);
Edward Rebar, El Cerrito, CA (US);
Andrew Jamieson, San Francisco, CA (US);
Qiang Liu, Foster City, CA (US);
Pei-Qi Liu, Richmond, CA (US);
Elizabeth J. Wolffe, Orinda, CA (US);
Stephen P. Eisenberg, Boulder, CO (US);
Eric Jarvis, Boulder, CO (US);
Sangamo BioSciences, Inc., Richmond, CA (US);
Abstract
Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.