The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2006
Filed:
Jul. 01, 1999
Michael Ploug, Copenhagen, DK;
Søren Østergaard, Copenhagen, DK;
Claus Holst-hansen, Frederiksberg, DK;
Ross Stephens, Charlottenlund, DK;
Keld Danø, Charlottenlund, DK;
Arne Holm, Holte, DK;
Michael Ploug, Copenhagen, DK;
Søren Østergaard, Copenhagen, DK;
Claus Holst-Hansen, Frederiksberg, DK;
Ross Stephens, Charlottenlund, DK;
Keld Danø, Charlottenlund, DK;
Arne Holm, Holte, DK;
Abstract
A novel set of inhibitors of the binding interaction between human urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR) has been developed. The inhibitors comprise of peptide fragments, monomeric or in multiple copies attached to a common scaffold, in which the amino acid sequence may include uncommon substituted amino acids to partially comprise of peptoid sequences. The present invention also relates to the use of such peptides in therapy, in particular for the treatment of cancer, having developed a modified non-human mammalian receptor to which the novel inhibitors are antagonistic.