The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Sep. 20, 2002
Raymond Cvetovich, Scotch Plains, NJ (US);
Robert Wenslow, East Windsor, NJ (US);
John M. Williams, Belle Mead, NJ (US);
Daniel Sidler, Whitehouse Station, NJ (US);
Louis Crocker, Belle Mead, NJ (US);
Hsien-hsin Tung, Edison, NJ (US);
Brian K. Johnson, Princeton, NJ (US);
Joseph Kukura, Ii, Somerset, NJ (US);
Ulf Dolling, Westfield, NJ (US);
Raymond Cvetovich, Scotch Plains, NJ (US);
Robert Wenslow, East Windsor, NJ (US);
John M. Williams, Belle Mead, NJ (US);
Daniel Sidler, Whitehouse Station, NJ (US);
Louis Crocker, Belle Mead, NJ (US);
Hsien-Hsin Tung, Edison, NJ (US);
Brian K. Johnson, Princeton, NJ (US);
Joseph Kukura, II, Somerset, NJ (US);
Ulf Dolling, Westfield, NJ (US);
Merck & Co. Inc., Rahway, NJ (US);
Abstract
The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I:or a salt thereof, wherein Rand R, are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.