The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
Dec. 22, 2000
Tadashi Fujii, Fujisawa, JP;
Yasuhide Aritoku, Fujisawa, JP;
Manabu Mukaihara, Kamakura, JP;
Takao Narita, Yatsushiro, JP;
Hitosi Agematu, Hadano, JP;
Kunio Isshiki, Zama, JP;
Tadashi Fujii, Fujisawa, JP;
Yasuhide Aritoku, Fujisawa, JP;
Manabu Mukaihara, Kamakura, JP;
Takao Narita, Yatsushiro, JP;
Hitosi Agematu, Hadano, JP;
Kunio Isshiki, Zama, JP;
Mercian Corporation, Tokyo, JP;
Abstract
A process for the production of L-pipecolic acid which comprises the step of reducing delta-1-piperideine-6-carboxylic acid by the use of pyrroline-5-carboxylate reductase. The delta-1-piperideine-6-carboxylic acid is obtained by the step of converting L-lysine by the use of lysine 6-aminotransferase encoded by a gene ofThe steps of reducing delta-1-piperideine-6-carboxylic acid and the converting of L-lysine into L-pipecolic acid by the use of lysine 6-aminotransferase are carried out by using a bacterium transformed with a gene encoding lysine 6-aminotransferase wherein such bacterium comprises pyrroline-5-carboxylate reductase encoded by a gene ofor a coryneform bacterium. A recombinant bacterium which can be used in this production process is also provided. Thus, the present invention can provide an efficient biological process for the production of L-pipecolic acid (or 2-piperidinecarboxylic acid).