The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2006
Filed:
May. 08, 2002
Joseph Schoeniger, Oakland, CA (US);
Albert W. Flounders, Berkeley, CA (US);
Robert C. Hughes, Albuquerque, NM (US);
Antonio J. Ricco, Los Gatos, CA (US);
Karl Wally, Lafayette, CA (US);
Stanley H. Kravitz, Placitas, NM (US);
Richard P. Janek, Oakland, CA (US);
Joseph Schoeniger, Oakland, CA (US);
Albert W. Flounders, Berkeley, CA (US);
Robert C. Hughes, Albuquerque, NM (US);
Antonio J. Ricco, Los Gatos, CA (US);
Karl Wally, Lafayette, CA (US);
Stanley H. Kravitz, Placitas, NM (US);
Richard P. Janek, Oakland, CA (US);
Sandia National Laboratories, Livermore, CA (US);
Abstract
The present invention discloses an electrochemical device for detecting single particles, and methods for using such a device to achieve high sensitivity for detecting particles such as bacteria, viruses, aggregates, immuno-complexes, molecules, or ionic species. The device provides for affinity-based electrochemical detection of particles with single-particle sensitivity. The disclosed device and methods are based on microelectrodes with surface-attached, affinity ligands (e.g., antibodies, combinatorial peptides, glycolipids) that bind selectively to some target particle species. The electrodes electrolyze chemical species present in the particle-containing solution, and particle interaction with a sensor element modulates its electrolytic activity. The devices may be used individually, employed as sensors, used in arrays for a single specific type of particle or for a range of particle types, or configured into arrays of sensors having both these attributes.