The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2006
Filed:
Jul. 10, 2000
William J. Boyle, Moorpark, CA (US);
David Lee Lacey, Newbury Park, CA (US);
Frank J. Calzone, Westlake Village, CA (US);
Ming-shi Chang, Tainan, TW;
William J. Boyle, Moorpark, CA (US);
David Lee Lacey, Newbury Park, CA (US);
Frank J. Calzone, Westlake Village, CA (US);
Ming-Shi Chang, Tainan, TW;
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis. Methods of treatment are described using the polypeptides in conjunction with various agents, including IL-1 inhibitors, TNF-α inhibitors, and serine protease inhibitors.