The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2006
Filed:
Sep. 14, 2000
Robert Terkeltaub, San Diego, CA (US);
Anne N. Murphy, Encinitas, CA (US);
James A. Dykens, Encinitas, CA (US);
Soumitra S. Ghosh, San Diego, CA (US);
Robert E. Davis, San Diego, CA (US);
Andrew E. Granston, Jr., San Diego, CA (US);
Robert Terkeltaub, San Diego, CA (US);
Anne N. Murphy, Encinitas, CA (US);
James A. Dykens, Encinitas, CA (US);
Soumitra S. Ghosh, San Diego, CA (US);
Robert E. Davis, San Diego, CA (US);
Andrew E. Granston, Jr., San Diego, CA (US);
MIGENIX Corp., San Diego, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention relates to improved diagnostic methods for early detection of a risk for developing an arthritic disorder in humans, and screening assays for therapeutic agents useful in the treatment of arthritic disorders, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.