The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2006
Filed:
May. 10, 2002
Applicants:
Bharat Aggarwal, Houston, TX (US);
Bryant G. Darnay, Houston, TX (US);
Sujay Singh, San Diego, CA (US);
Inventors:
Bharat Aggarwal, Houston, TX (US);
Bryant G. Darnay, Houston, TX (US);
Sujay Singh, San Diego, CA (US);
Assignee:
Research Development Corporation, Carson City, NV (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/475 (2006.01); C07K 19/00 (2006.01); C12N 5/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.