The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2006
Filed:
Nov. 21, 2001
George M. Grass, Tahoe City, CA (US);
Glen D. Leesman, Hamilton, MT (US);
Daniel A. Norris, San Diego, CA (US);
Patrick J. Sinko, Lebanon, NJ (US);
John E. Wehrli, Mountain View, CA (US);
George M. Grass, Tahoe City, CA (US);
Glen D. Leesman, Hamilton, MT (US);
Daniel A. Norris, San Diego, CA (US);
Patrick J. Sinko, Lebanon, NJ (US);
John E. Wehrli, Mountain View, CA (US);
Lion Bioscience AG, Heidelberg, DE;
Abstract
A secondary compound library produced by a method of screening a compound library or portion thereof by absorption is provided. The method includes a step (i) that screens a primary compound library or portion thereof having a plurality of test samples containing isolated compounds or isolated mixtures of compounds per test sample by generating an in vivo absorption profile for each of the test samples from initial dose data and from in vitro bioavailability data comprising permeability and solubility data for each of the test samples, wherein the absorption profile includes at least one of rate of absorption, extent of absorption, and concentration of a test sample. Step (ii) produces a secondary compound library that includes at least one compound from the primary compound library having a desired absorption profile.