The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2006
Filed:
Feb. 19, 2003
Erik Christenson, Bellevue, WA (US);
Anthony J. Demaggio, Kirkland, WA (US);
Phyllis S. Goldman, Bothell, WA (US);
David L. Mcelligott, Bothell, WA (US);
Erik Christenson, Bellevue, WA (US);
Anthony J. DeMaggio, Kirkland, WA (US);
Phyllis S. Goldman, Bothell, WA (US);
David L. McElligott, Bothell, WA (US);
ICOS Corporation, Bothell, WA (US);
Abstract
The invention provides a novel human poly(ADP-ribose) polymerase (hPARP2) polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, and host cells transformed with the expression constructs. Also provided are methods for producing the hPARP2 polypeptides, antibodies that are immunoreactive with the hPARP2 polypeptides. In addition, there are provided methods for identifying specific binding partners of hPARP2, and more particularly methods for identifying binding partners that modulate biological activity of hPARP2. Methods of modulating biological activity of hPARP2 in vitro and in vivo are also provided.