The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2006
Filed:
Nov. 12, 1999
Patricia Guerry, Silver Spring, MD (US);
Lanfong H. Lee, Silver Spring, MD (US);
Edward Burg, Manassas, VA (US);
Trevor J. Trust, Sherborn, MA (US);
Patricia Guerry, Silver Spring, MD (US);
Lanfong H. Lee, Silver Spring, MD (US);
Edward Burg, Manassas, VA (US);
Trevor J. Trust, Sherborn, MA (US);
The United States of America as represented by the Secretary of the Navy, Washington, DC (US);
Abstract
This invention comprises a recombinant protein comprising the maltose binding protein (MBP) offused to amino acids 5–337 of the FlaA flagellin ofVC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of81–176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin fromspp. for use as a component of a vaccine againstdiarrhea. The invention therefore represents an effective treatment againstbut avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused bymolecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.