The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2006
Filed:
Apr. 27, 1999
Tao Chen, Richmond, CA;
Yuehua He, Vancouver, CA;
Peter Cullis, Vancouver, CA;
Thomas Madden, Vancouver, CA;
Peter Scherrer, Vancouver, CA;
David Tirrell, Sunderland, MA (US);
Phalgun Joshi, Vancouver, CA;
Jung Soo Kim, Amherst, MA (US);
Tao Chen, Richmond, CA;
Yuehua He, Vancouver, CA;
Peter Cullis, Vancouver, CA;
Thomas Madden, Vancouver, CA;
Peter Scherrer, Vancouver, CA;
David Tirrell, Sunderland, MA (US);
Phalgun Joshi, Vancouver, CA;
Jung Soo Kim, Amherst, MA (US);
Inex Pharmaceuticals Corporation, Burnaby, CA;
Abstract
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make pH-sensitive liposomes which become unstable, permeable or fusogenic with certain pH changes. In addition, this invention generally describes methods for delivering therapeutic compounds and drugs to target cells by administering to a host the pH-sensitive liposomes of the present invention.