The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2006

Filed:

Jul. 01, 2003
Applicants:

Daisy Joe Du Bois, Palo Alto, CA (US);

Long Mao, San Diego, CA (US);

Daniel Harry Rogers, San Diego, CA (US);

John Patrick Williams, San Diego, CA (US);

Inventors:

Daisy Joe Du Bois, Palo Alto, CA (US);

Long Mao, San Diego, CA (US);

Daniel Harry Rogers, San Diego, CA (US);

John Patrick Williams, San Diego, CA (US);

Assignee:

Roche Palo Alto LLC, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 31/506 (2006.01); A31P 11/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of Formula (I):wherein Aris aryl; Aris hydrogen, cycloalkyl, aryl or heteroaryl; Z is —C(═O) or a single bond; R, R, R, Rand Rare independently hydrogen or alkyl optionally substituted with hydroxy; alk is an alkylene chain of one to six carbon atoms; X is —O—, —NR(where Ris hydrogen or alkyl), (CRR)(where Rand Rare independently in each occurrence hydrogen or alkyl and m is an integer from 0 to 3), or —S(O)(wherein n is an integer from 0 to 2); or prodrugs thereof, and pharmaceutically acceptable salts thereof,are inhibitors of CCR3 useful for treating eosinophil induced diseases such as asthma.


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