The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2005
Filed:
Nov. 06, 2001
William Pendergast, Durham, NC (US);
Benjamin R. Yerxa, Raleigh, NC (US);
Janet L. Rideout, Raleigh, NC (US);
Suhaib M. Siddiqi, Raleigh, NC (US);
William Pendergast, Durham, NC (US);
Benjamin R. Yerxa, Raleigh, NC (US);
Janet L. Rideout, Raleigh, NC (US);
Suhaib M. Siddiqi, Raleigh, NC (US);
Inspire Pharmaceuticals, Inc., Durham, NC (US);
Abstract
The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Yand/or P2Ypurinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment as well as facilitating sputum induction and expectoration.