The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2005
Filed:
Sep. 30, 1999
Doris Huebler, Schmieden, DE;
Guenter Kaufmann, Jena, DE;
Michael Oettel, Jena, DE;
Holger Zimmermann, Ilmenau-Roda, DE;
Michael Dittgen, Apolda, DE;
Sabine Fricke, Jena, DE;
Manfred Boese, Jena, DE;
Ralf Ladwig, Jena, DE;
Sven Claussen, Jena, DE;
Carsten Timpe, Weissenborn, DE;
Doris Huebler, Schmieden, DE;
Guenter Kaufmann, Jena, DE;
Michael Oettel, Jena, DE;
Holger Zimmermann, Ilmenau-Roda, DE;
Michael Dittgen, Apolda, DE;
Sabine Fricke, Jena, DE;
Manfred Boese, Jena, DE;
Ralf Ladwig, Jena, DE;
Sven Claussen, Jena, DE;
Carsten Timpe, Weissenborn, DE;
Jenapharm GmbH & Co. KG, Jena, DE;
Abstract
The method of making a bioadhesive tablet for controlling testosterone blood level, especially in elderly men suffering from partial androgen deficiency, includes spray-drying an alcoholic solution or suspension of testosterone and at least one testosterone ester, preferably in a ratio of 1:10 to 1:1.5, separately or together, with an organic polymer and optionally one or more auxiliary ingredient to form an active ingredient premix. Then various other auxiliary ingredients are mixed, as needed, with the active ingredient premix to form the bioadhesive tablet with an active ingredient layer and an adhesive layer. The active ingredient layer contains an effective amount of the active ingredient premix. The adhesive layer includes auxiliary ingredients including the bioadhesive polymer. The bioadhesive tablet may be buccally administered to provide a predetermined timed release profile of testosterone, advantageously varying according to a circadian rhythm.